ISSN: 2249–9504
CAS CODEN: IJPCDX

SOLUBILITY ENHANCEMENT OF A DRUG BY LIQUISOLID TECHNIQUE

Abstract

Author(s): More Swati K

This approach is suitable for immediate or sustain release formulations. Liquisoild technique is a novel concept for delivery of drugs through oral route. This approach of delivering drugs is suitable mostly for lipophilic drugs and poorly or water insoluble drugs. The “Liquisolid” technique is a novel and capable addition towards such an aims for solubility enhancement and dissolution improvement, thereby it increases the bioavailability. Increasing the solubility by using a non-volatile solvent which is suitable for drug, there by dissolving the drug in the nonvolatile solvent and this is termed as liquid medicament. Blending the liquid medicament with mixture of carrier and coating material, liquid medicament can be converted into non adhere, dry looking powder with acceptable flow properties and compression behaviour using suitable excipients and tabletting by direct compression method. This technique is an efficient method for formulating water insoluble and water soluble drugs. This technique is based upon the admixture of drug loaded solutions with appropriate carrier and coating materials.

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