ISSN: 2249–9504
CAS CODEN: IJPCDX

PREPARATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF ATORVASTATINBY IONIC GELATION TECHNIQUE

Abstract

Author(s): G. Rama Krishna*, M. Ravi, D.Srinivasa Rao and S.Ramu

A primary object of using mucoadhesive formulations orally would achieve a substantial increase in the length of stay of the drug in GI tract stability problem in the intestinal fluid can be improved. Mucoadhesive microsphere carrier systems were made from the biodegradable polymers in sustained drug delivery.The objective of the presentstudy is related to the preparation and evaluation of mucoadhesive microspheres of Atorvastatin by using different polymers like Sodium alginate, HPMC K100M, Sodium CMC, Ethyl cellulose, Methyl cellulose, Guar gum, Xanthan gum and Carbopol 940 in different ratios by Ionic gelation method. The prepared batches ofmucoadhesive microspheres of Atorvastatin were evaluated for theflow properties;drug content, entrapment efficiency,and Percentmucoadhesive property,in vitrodissolution studies of all 12 formulations were performed. From the all batches F10 (Drug: Sod. Alginate : Methyl cellulose 1:2:1) batch is considered to be the most promising formulation batch because among all the batches it shows better extent of drug release 97.11% (8hrs) , good entrapment efficiency (78%), and in vitro wash-off test shows good mucoadhesive property. Atorvastatinrelease from alginate Methyl cellulose (F10) was slow and extended over a period of 8 hrs and these microsphereswere found suitable for the oral controlled release formulation.

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