ISSN: 2249–9504
CAS CODEN: IJPCDX

PREFORMULATION, PRCOMPRESSION AND POST COMPRESSION EVALUATION OF BILAYER TABLET OF ASPIRIN AS IMMEDIATE RELEASE AND NICOTINIC ACID AS SUSTAINED RELEASE

Abstract

Author(s): Vikash Sharma, Mithun Bhowmick, Vaishali Rathi and Jagdish Rathi

Development of a single dosage form (bilayered tablet) containing two or more pharmaceutical active ingredients have been increased in the pharmaceutical industry. This promotes patient compliance and convenience. These are novel drug delivery systems where combination of two or more drugs in a singleunit having different drug release profiles (immediate release and sustained release). This prolongs the drug action with better control of plasma drug levels. The present investigation is aimed to formulate and evaluate bilayer sustained release floating tablets containing immediate release layer of aspirin and sustained release layer nicotinic acid (niacin).In this work Preliminary Preformulation, Pre-compression and Post-compression parameters of tablets were investigated.

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