ISSN: 2249–9504
CAS CODEN: IJPCDX

INVITRO ANTICANCER ACTIVITY OF TECOMASTANS (L.) ETHANOLIC LEAF EXTRACT ON HUMAN BREAST CANCER CELL LINE (MCF-7)

Abstract

Author(s): M.Thirumal*, G.Kishore,R.Prithika, Sampa Dasand G.Nithya

Tecomastans(L.) (Family:Bignoniaceae) is called as yellow elder in english.Traditionally flowers and bark are used for treatment of various cancers. In current studyCrude ethanolic leaf extract of Tecomastans(L.)leaves were examined for their anticancer activity. To determine invitroanticancer activity, different concentrations of crude extract were tested on MCF-7 cancer cell line by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Tecomastansleaf extract showed a significant antiproliferative activity and a dose dependent effect was observed. Minimum inhibition of 14.6 % was shown by extract at concentration 7.8 μg/ml and maximum inhibition (95.9%) was observed at 1000 μg/ml. The plant extract showed activity in potential range for further investigation on cancer cells.

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