ISSN: 2249–9504
CAS CODEN: IJPCDX

DEVELOPMENT AND CHACTERIZATION OF SITE SPECIFIC SUSTAINED RELEASE MICROSPHERES FOR INTESTINAL INFECTION

Abstract

Author(s): DS.Goswami*and S.Kashyap

The present work was to develop and characterized site specific sustained release microspheres for intestinal infection. Hydrocortisone have the anti-inflammatory property so used to treat the intestinal infection whichis caused by an overactive immune system, resulting in ulcers and inflammation along the lining of rectum and colon. So oral Hydrocortisone is prescribed to treat more severe symptoms of colitis. Coating was done with the colon specific polymer eudragit S100 and sodium alginate used as a matrix polimer and HPMC K4M and gellan gum was used as mucoadhesive polymers. Hydrocortisone mucoadhesive microspheres were prepared by orifice ionic gelation method. The prepared formulations were characterized for various physicochemical parameters such as particle size, percentage yield, drug entrapment efficiency, loose surface crystal study, surface accumulation study, % moisture loss, swelling poperties, wash off test and in vitro drug release of mucoadhesive microsphere at different pH up to 12 hrs. The drug entrapment efficiency of all formulations was reported as high profile ranges 80-97.44% and the surface pH in the ranges between 6.80 -7.02. The swelling index in the range 51.11-88.12%. It was found that the F1shows the best cumulative drug release up to 12 hrs of the period. Hence it was concluded that the polymer possess substantial release with good mucoadhesion properties could be used for sustained drug delivery.

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