ISSN: 2249–9504
CAS CODEN: IJPCDX

UV ?SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF RALTEGRAVIRIN BULK AND TABLET DOSAGE FORM

Abstract

Author(s): B. Siddartha1*and I. Sudheer Babu2

A simple, precise and accurate UV Spectrophotometric method has been developed and validated for estimation of Raltegravir in bulk and tablet dosage form. In this method Raltegravirshows λmax at 290nm using 0.1N NaOHas a solvent and calibration graphs were plotted over the concentrations ranging from 10 to 60μg/ml of Raltegravir with correlation coefficient 0.999. The proposed method was validated as per ICH Q2 (R1) guidelines for precision, linearity, accuracy and recovery. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.311μg/ml and 0.941μg/mlrespectively by simple UV spectroscopy. The proposed method was validated

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