Author(s): RV. Nagarjuna*, G. Jaya Krishna, V. Kameshwara Rao, CH. Balaji, M. Prabhudeva, A. Ravi Kumar, A. Jaya Rami Reddy, V. Vallabh
The present investigation was carried out to evaluate the safety of methanolic extract from leaves by determining its potential toxicity after acute and sub acute administration in mice. For the acute study, extract of Morinda citrifolia was administrated to mice in single doses given by oral route. General behavior adverse effects and mortality were determined up to7 days. In the Sub acute study, the extract was administered orally at doses of 200 and 400 mg/kg for 28 days to mice Biochemical and hematological parameters were determined at the end of 28 days of daily administration. The studies on sub acute toxicity reveals that no mortalities or evidence of adverse effects have been observed in mice following acute oral administration at the highest dose of 2000mg/kg crude extract of . In sub acute toxicity study daily oral administration of methanolic extract of 200 and 400 mg/kg Morinda citrifolia body weight of extract of Morinda citrifolia for up to 28 days did not result in death or significant changes in body weight, Hematological and Biochemical parameters were done and tabulated.