ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

THE RELATIONSHIP BETWEEN BODY IRON STORE AND INSULIN RESISTANCE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME TREATED BY METFORMIN

Abstract

Author(s): ZarkaaKhairi AL-Tahafi1 and Wahda Basheer Al-Youzbaki

Objective: To evaluate the effect of metformin on body mass index (BMI) and waist to hip (W/H) ratio and on insulin and ferritin serum level, and insulin resistance represented by Homeostasis Model Assessment (HOMA-IR).And to assess the relationship between serum ferritin and the above parameters in patients with polycystic ovary syndrome (PCOS), treated by metformin for more than three months. Methodology: This study is a case-control study, which was adopted in the Fertility and Invitro Fertilization (IVF) Center in AL. Batoll Teaching Hospital Mosul City/ Iraq, in the period between 1st of November 2013 and 1st April 2014. A group of 39 women with PCOS of reproductive age who used metformin for more than three months (metformin users) with another age-and BMI matched group of 47 women with PCOS who didn’t use metformin (metformin non-users), these groups were sub-divided into subgroups according to the BMI to (obese and non-obese). A 10 ml of fasting blood sample was taken from each PCOS woman of the two groups. The serum was used to measure serum insulin and ferritin level by using commercially available kits, whereas; BMI and insulin resistance represented by Homeostasis Model Assessment (HOMA) was calculated by using especial equations. Results: This study revealed that about half (53 %) of the studied PCOS patients (with and without metformin therapy) found to be obese. There were significant higher mean serum insulin and ferritin level and HOMA-IR value in the obese in comparison with non obese metformin non-users PCOS women. There were a significant lower mean serum level of insulin and ferritin in obese metformin users as compared with obese metformin non-users. Insulin level of obese metformin non-users of the studied PCOS patients found to be above the normal range (<20 μIU/ ml), but there were a non significant differences in the mean FSG between the same two groups. There are no significant differences between all these parameters of the non-obese metformin users and non-users, also insulin level of all non obese studied PCOS patients (metformin users and non-users) found to be within the normal range. There were a significant positive correlation between BMI and serum insulin level, BMI and serum ferritin level, serum insulin and HOMA-IR value, and insulin and ferritin level in metformin users and non-users PCOS patients. By using linear stepwise multiple regression, this study showed a significant effect of the nondepended variables W/H ratio and HOMA-IR on insulin level in obese metformin users. This study concluded that obesity is an important factor that affects insulin resistance and hyperinsulinemia lead to increase ferritin level as this study found a significant correlation between serum insulin and ferritin level in metformin users which was also very highly significant in non-metformin users PCOS patients.

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