ISSN: 2249-9504
CAS CODEN: IJPCDX

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Google Scholar citation report
Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

SYNTHESIS OF SOME NOVEL 4, 6-DISUBSTITUTED DERIVATIVES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITY

Abstract

Author(s): Sucheta Gautam1* , Dharmendra Mishra2, Ranjit Singh2 and DK Pal1

In view of the link between use of NSAIDs and altered antimicrobial agents and a growing evidence of COX-II implications in angiogenesis, a novel series of 4, 6-substituted quinazoline derivatives have been synthesized starting from anthranilic acid derivatives through conventional methods. Initially acylation followed by cyclisation to obtain benz-oxazinones which on further treatment with ammonia yielded the crucial intermediate, 2-substituted benzamide. The products were subsequently cyclised to obtain quinazolones, chlorinated, then hooked to have various 4, 6-disubstituted quinazoline derivatives. All the derivatives are screened for anti-microbial activity

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