Abstract
Author(s): Sucheta Gautam1* , Dharmendra Mishra2, Ranjit Singh2 and DK Pal1
In view of the link between use of NSAIDs and altered antimicrobial agents and a growing evidence of COX-II implications in angiogenesis, a novel series of 4, 6-substituted quinazoline derivatives have been synthesized starting from anthranilic acid derivatives through conventional methods. Initially acylation followed by cyclisation to obtain benz-oxazinones which on further treatment with ammonia yielded the crucial intermediate, 2-substituted benzamide. The products were subsequently cyclised to obtain quinazolones, chlorinated, then hooked to have various 4, 6-disubstituted quinazoline derivatives. All the derivatives are screened for anti-microbial activity