ISSN: 2249–9504
CAS CODEN: IJPCDX

SYNTHESIS OF SOME NOVEL 4, 6-DISUBSTITUTED DERIVATIVES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITY

Abstract

Author(s): Sucheta Gautam1* , Dharmendra Mishra2, Ranjit Singh2 and DK Pal1

In view of the link between use of NSAIDs and altered antimicrobial agents and a growing evidence of COX-II implications in angiogenesis, a novel series of 4, 6-substituted quinazoline derivatives have been synthesized starting from anthranilic acid derivatives through conventional methods. Initially acylation followed by cyclisation to obtain benz-oxazinones which on further treatment with ammonia yielded the crucial intermediate, 2-substituted benzamide. The products were subsequently cyclised to obtain quinazolones, chlorinated, then hooked to have various 4, 6-disubstituted quinazoline derivatives. All the derivatives are screened for anti-microbial activity

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