ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

SYNTHESIS OF 1, 2 DI-SUBSTITUTED QUINAZOLINONE DERIVATIVES AND THEIR ANTI-MICROBIAL SCREENING

Abstract

Author(s): KunwarPratap Singh*, Lokesh Kumar Sharma, Lal Ratnakar Singh,Gaurav Garg and Milind Pande

Quinazolinone is a compound made up of two fused six member simple aromatic benzene ring and a number of substituted quinazolinone are known for their biological importance like anti-cancer, anti-biotic, anti-microbial, anti-HIV, anti-oxidant, anti-tubercular, anti-malarial, anti-viral, anti-psychotics and anti-inflammatory activity. In the present investigation an attempt has been made for the 1,2 di-substituted quinazolinone, using N-substituted derivative of aniline & derivative of aldehyde. Further these 1,2 di-substituted quinazolinone has condensed with various primary amine containing drug like acetamide, sulfanilamide, thiourea and with aromatic amine like o-chloro benzoic acid, derivative of aniline and derivative of aldehyde. The synthesized compound have been established on the basis of Infra-Red, Nuclear Magnetic Resonance spectral data, Thin Layer Chromatography and Melting Point or Boiling Point .These compound are also screened for biological activity like anti-microbial activity using standard disk method by measuring inhibition of zone. Ceftriaxone was used as standard drug. The synthesized compound was shown to good anti-microbial activity as compared with standard.

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