ISSN: 2249–9504
CAS CODEN: IJPCDX

SYNTHESIS OF 1, 2 DI-SUBSTITUTED QUINAZOLINONE DERIVATIVES AND THEIR ANTI-MICROBIAL SCREENING

Abstract

Author(s): KunwarPratap Singh*, Lokesh Kumar Sharma, Lal Ratnakar Singh,Gaurav Garg and Milind Pande

Quinazolinone is a compound made up of two fused six member simple aromatic benzene ring and a number of substituted quinazolinone are known for their biological importance like anti-cancer, anti-biotic, anti-microbial, anti-HIV, anti-oxidant, anti-tubercular, anti-malarial, anti-viral, anti-psychotics and anti-inflammatory activity. In the present investigation an attempt has been made for the 1,2 di-substituted quinazolinone, using N-substituted derivative of aniline & derivative of aldehyde. Further these 1,2 di-substituted quinazolinone has condensed with various primary amine containing drug like acetamide, sulfanilamide, thiourea and with aromatic amine like o-chloro benzoic acid, derivative of aniline and derivative of aldehyde. The synthesized compound have been established on the basis of Infra-Red, Nuclear Magnetic Resonance spectral data, Thin Layer Chromatography and Melting Point or Boiling Point .These compound are also screened for biological activity like anti-microbial activity using standard disk method by measuring inhibition of zone. Ceftriaxone was used as standard drug. The synthesized compound was shown to good anti-microbial activity as compared with standard.

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