ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

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SYNTHESIS, CHARACTERIZATION, ANTIOXIDANT AND ANTIBACTERIAL PROPRIETIES OF CHITOSAN ASCORBATE

Abstract

Author(s): J. Hafsa1*, B. Charfeddine1, M.A. Smach1, K. Limem1, H. Majdoub2and R. Sonia2

In this study, chitosan ascorbate(CHAA) was synthesized through the Schiff base reaction and characterized with Fourier transformed infrared spectroscopy (FTIR), the solubility of CHAA in distilled water was greatly improved. The antioxidant activity of CHAA compared to chitosan (CH) wasperformed by four different analytical assays (DPPH, TBARS, NO, H2O2); the results showed that CHAA exhibited a higher antioxidant activity than that CH. The minimum inhibitory concentrations of CH and CHAA against five bacteria (E. coli, P. aeruginosa, S. Typhimurium, L. monocytogenes, S. aureus) were tested; the antibacterial efficacy of CHAA is lower than that of CH because of the consumption of some amine groups on chitosan during the grafting process. However, CHAA still possesses antibacterial efficacy against both bacteria. Combining chitosan and ascorbic acid improve the antioxidant activity of CH, and still possesses antibacterial efficacy against both bacteria

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