ISSN: 2249–9504
CAS CODEN: IJPCDX

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL PYRIMIDINE LINKED INDOLES WITH ?-LACTAMS AND [1,2,4]TRIAZOLO[4,3-C]MOIETIES

Abstract

Author(s): V. Prabhakar*, K. SudhakarBabu, LK. Ravindranath, J. Latha, Bolla Krishnavenu

Objectives: To synthesize a variety of Pyrimidine analogs 3, 5, 6, 8(a-e), 9(a-e) and their anti fungal activity was determined.

Methods: Using 2,4 di chloro Pyrimidine and hydrazine hydrate ,new compounds are established on the basis of FT-IR,1H NMR, and mass spectral data. Anti fungal activity was done by disc diffusion method.

Results: All the compounds were synthesized in good yield. Among the new compounds 9a,9b are found to most potent anti fungal activity.

Conclusions: The results obtained justify the usage of these compounds from their promising antibacterial activity. Therefore, the nature of group is very important for antibacterial activity in disc diffusion model.

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