Author(s): V. Prabhakar*, K. SudhakarBabu, LK. Ravindranath, J. Latha, Bolla Krishnavenu
Objectives: To synthesize a variety of Pyrimidine analogs 3, 5, 6, 8(a-e), 9(a-e) and their anti fungal activity was determined.
Methods: Using 2,4 di chloro Pyrimidine and hydrazine hydrate ,new compounds are established on the basis of FT-IR,1H NMR, and mass spectral data. Anti fungal activity was done by disc diffusion method.
Results: All the compounds were synthesized in good yield. Among the new compounds 9a,9b are found to most potent anti fungal activity.
Conclusions: The results obtained justify the usage of these compounds from their promising antibacterial activity. Therefore, the nature of group is very important for antibacterial activity in disc diffusion model.