ISSN: 2249–9504
CAS CODEN: IJPCDX

SYNTHESIS, CHARACTERISATION AND BIOLOGICAL ACTIVITY OF SOME NOVEL AZETIDINONES FROM NAPHTHO [2,1-b]THIOPHENE

Abstract

Author(s): K. Veena1, M. Ramaiah2* and VP. Vaidya3

The reaction of ethyl naphtho[2,1-b]thiophene-2- carboxylate 2 with hydrazine hydrate produced naphtho[2,1-b]thiophene-2-carbohydrazide 3 which upon treatment with various aromatic aldehydes produced Schiff bases i.e. N-(aryl-methylene) substitutednaphtho[2,1-b]thiophene-2-carbohydrazides 4a-f which served as an excellent intermediate for the synthesis of titled compounds. The Schiff bases 4a-f readily underwent cyclisation upon reaction with chloroacetyl chloride in presence of triethyl amine to yielded azetidinones 5a-f. The Structures of the newly synthesized compounds have been established by analytical and spectral studies. All the synthesized compounds were evaluated for antibacterial, antifungal and antioxidant activities.

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