Author(s): Houssou Raymond Fatondji1, Salome Kpoviessi1* , Fernand Gbaguidi2, Latifou Lagnika3, Joachim Gbénou4, Georges Coffi Accrombessi1, Sanni Ambaliou3, Mansourou Moudachirou4 and et Jacques Poupaert5
Semicarbazones and thiosemicarbazones are inhibitors of DNA replication. This activity, which is explained by their chelating property of certain metal ions cofactors of enzymes involved in the replication of DNA, justifies their use as antimicrobials. Our work was aimed at synthesizing and studying the action of certain semicarbazones and thiosemicarbazones on strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Enterococcus faecalis. After their synthesis, the semicarbazones and thiosemicarbazones of six arylketones were identified by their IR, 1H and 13C NMR spectra and in mass spectrometry. The biological activity of these compounds was tested in vitro against the growth of strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Enterococcus faecalis. Thiosemicarbazones 1b and 5b, the most lipophilic compounds, had reproducibly exerted an inhibitory effect on the growth of the studied bacteria.