ISSN: 2249–9504
CAS CODEN: IJPCDX

SYNTHESIS AND CHARACTERIZATION OF SUBSTITUTED 1,3,4 THIADIAZOLE AS POTENTIAL ANTIMICROBIAL AGENTS

Abstract

Author(s): Manimaran T*, Anand Raj M, Jishala MI, Gopalasatheeskumar K, Parthiban S and Boopathi T

Background: Heterocyclic chemistry continues to draw the attention of synthetic organic chemists and is of great scientific interest. Objective: The present study was undertaken to assess the synthesis and characterization of substituted 1,3,4 thiadiazole as potential antimicrobial agents. Materials and Methods: synthesis of three (TDZ1, TDZ2, TDZ3) substituted hetero cyclic compounds and the study its Physio-chemical properties and structural interpretation by IR spectroscopy and NMR spectrum. And in vitro antifungal and antibacterial activities performed by nutrient agar medium. Results: All the compounds were screened for antibacterial activity. However the compounds TDZ 1 and TDZ 2 have shown promising antibacterial activity, while the remaining compound such as TDZ 3 have also shown moderate antibacterial activity, when compared with the standard drug Ciprofloxacin. Compounds TDZ 1 and TDZ 2 have shown promising antifungal activity, while the remaining compound such as TDZ 3 have also shown moderate antifungal activity, when compared with the standard drug Griseofulvin. Conclusion: In this work is concluded that there exists ample scope for the medicinal chemists to further study in this class of compounds and used for the treatment of various types of deadly microbial infections.

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