ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

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SYNTHESIS AND CHARACTERIZATION OF NOVEL 1, 3, 4-THIADIAZOLE DERIVATIVES AND SCREENING FOR CERTAIN BIOLOGICAL ACTIVITIES

Abstract

Author(s): Lincy Joseph, Mathew George andPrabha Mathews*

In the presentstudy 5-aryl N-phenyl-1, 3, 4-thiadiazole 2-amino derivatives (PM1-PM10) were synthesized by the oxidative cyclization of substituted phenyl thiosemicarbazone using FeCl3as catalyst. The chemical structures of the synthesized compounds were confirmed byIR, H1NMR and CHNS analysis. These compounds were screened for antibacterial, anti inflammatory, anti diabetic, anti oxidant, anxiolytic and locomotor activities. N-phenyl 5-(2, 3, 4-trimethoxyphenyl)-1, 3, 4 thiadiazole-2-amine showed maximum antibacterial and anti inflammatory activities, N,5-diphenyl 1, 3,4 thiadiazole -2-amine showed maximum antioxidant and anxiolytic activity, N-phenyl 5-(2, 4-dimethoxyphenyl)-1, 3, 4 thiadiazole-2-amine showed maximum anti diabetic activity and N-phenyl 5-( 3-bromophenyl)-1, 3, 4 thiadiazole-2-amine showed maximum anxiolytic activity

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