ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

SYNTHESIS AND ANTI-MICROBIAL SCREENING OF SOME NOVEL QUINAZOLINONE DERIVATIVES

Abstract

Author(s): L. Ratnakar Singh*, KunwarP.Singh,Milind Pande and Mohammad ShaharYar

A number of substituted quinazolinone are known for their biological importance like anti-microbial, anti-inflamatory, anticancer, antifungal, antimalarial, anti-viral, anti-psychotics activity. In the present investigation an attempt has been made for the synthesis of quinazolinone derivatives. Further these synthesized of quinazolinone derivatives has been condensed with various primary amine containing drug like sulfonalamide, sulfanilamide, acetamides, thiourea, urea, pyrimethamine and with aromatic amine like 2-amino benzoic acid, aniline. The synthesized compound have been confirmed by IR, and NMR spectral data. These compounds were also screened for various biological activities like anti-microbial activity by standard methods. The synthesized compound compound has shown moderate to good anti-microbial activity and some synthesized compound has shown significant as compared with standard.

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