ISSN: 2249–9504
CAS CODEN: IJPCDX

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL5-(8-BROMONAPHTHO[2,1-B]FURAN-2-YL)-N-ALKYL/ARYL-1,3,4-THIADIAZOLE-2-AMINES AND 5-(8-BROMONAPHTHO[2,1-B]FURAN-2-YL-4-SUSTITUTED -4H-1,2,4-TRIAZOLE-3-THIOLS

Abstract

Author(s): D. Ramesh, MN. Kumaraswamy, KM. Nagarsha

The key starting material 8-bromonaphtho [2,1-b]furan-2-carboxyhydrazide 1 was utilized for the synthesis of the title compounds. The carbohydrazide1 was converted into thiosemicarbazide 2a-e by the condensation of appropriate alkyl/arylisothiocyanates These thiosemicarbazides were cyclized using anhydrous phosphoric acid to 5-(8-bromonaphtho[2,1-b]furan-2-yl)-N-alkyl/aryl-1,3,4-thiadiazole2-amines (3a-e).The thiosemicarbazides 2a-e were cyclized using aqueous sodium hydroxide to 5-(8- bromonaphtho[2,1-b]furan-2-yl-4-sustituted-4H-1,2,4-triazole-3-thiols 3a-e. The structures of newly synthesized compounds have been established by analytical and spectral studies. All the compounds in the series have been screened for their antibacterial and antifungal activities.

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