Author(s): Ahmed I Khattab1* , Hanan E Babiker2 and Humodi A Saeed3
In spite of the large number of antibacterial compounds that have been discovered till now, most pathogenic bacteria have become resistant to these compounds. Therefore, searching for new antibacterial compounds is of increasing urgency. The aims of this study were to isolate Streptomyces species from Red Sea sediments as well as to screen the isolate(s) for antibacterial compounds. Soil samples were collected from in-depth sediments in the Red Sea in the neighborhood of Port-Sudan. The samples were cultivated on Starch Casein Agar. Adoption of Overlay Method after overnight incubation, resultant in isolation of many promising strains. The strains have activities against both Gram-positive and Gram-negative bacteria. Molecular assay was carried out to confirm the identity of the isolated strains using 16s rDNA gene sequence. The sequence similarities of the isolates were found to be varying from 92% to 99% of the Streptomyces deposited in the NCBI GeneBank. This study provides recent information about bioactivity of the Red Sea Streptomyces and proved that this unexplored habitat may be a promising source for antibacterial compounds.