ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

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STABILITY INDICATING UPLC METHOD FOR SIMULTANEOUS ESTIMATION OF LAMIVUDINE, ABACAVIR AND DOLUTEGRAVIR FROM ITS TABLET DOSAGE FORM

Abstract

Author(s): Nagaraju Pappula*, Naresh Nagubandi

A novel stability indicating Ultra performance liquid chromatography (UPLC) method has been developed and validated for the simultaneous estimation of Abacavir, Dolutegravir and Lamivudine in the tablet dosage form. Chromatographic separations were carried using Inspire (50 mm x 2.1 mm) 1.8 μm column with a mobile phase composition of phosphate buffer (pH 6) and Acetonitrile in the gradient program have been delivered at a flow rate of 0.3ml/min and the detection was carried out using UV detector at wavelength 242 nm. The retention time for Lamivudine, Abacavir and Dolutegravir were 0.965, 1.528 and 2.186 minutes respectively. The correlation coefficient values in linearity were found to be 0.999 and concentration range 30-150 μg/ml, 60-300 μg/ml and 5-25µg/ml respectively. The results of study showed that the proposed RP-UPLC method is a simple, accurate, precise, rugged, robust, ultra-fast and reproducible, which may be useful for the routine estimation of Lamivudine, Abacavir and Dolutegravir in pharmaceutical dosage form.

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