ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

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STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF TELMISARTAN AND HYDROCHLOROTHIAZIDEIN PHARMACEUTICAL DOSAGE FORM

Abstract

Author(s): PSRCHNP. Varma D, A. Lakshmana Rao* and SC. Dinda

A simple, fast and precise reverse phase, isocratic HPLC method was developed for the separation and quantification of telmisartan and hydrochlorothiazide in pharmaceutical dosage form. The quantification was carried out using ProntoSIL C18-EPS 4.6X150mm, 3μm enhanced polar selectivity column and mobile phase comprised of potassium dihydrogen phosphate buffer pH adjusted to 3.2 ± 0.5 with orthophosphoric acid and acetonitrile in proportion of ratio 55:45 and degassed under ultrasonication. The flow rate was 0.8mL/min and the effluent was monitored at 271nm. The retention time of telmisartan and hydrochlorothiazide were 5.01±0.5 and 2.94±0.5 respectively. The method was validated in terms of linearity, precision, accuracy, specificity, limit of detection and limit of quantitation. Linearity of telmisartan and hydrochlorothiazide were in the range of 15.01 to 75.05μg/mL and 5.02 to 25.10μg/mL respectively. The percentage recoveries of both the drugs were 100.8% and 99.5% for telmisartan and hydrochlorothiazide respectively from the tablet formulation. The proposed method is suitable for simultaneous determination of telmisartan and hydrochlorothiazide in pharmaceutical dosage form

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