Author(s): G. Raveendra Babu1*, A. Lakshmana Rao2, SriLakshmisurekha.P1,T.Kalapraveen1and P.SambhasivaRao3
Simple, accurate, precise, sensitive and highly selective spectrophotometric methods were developed for the estimation of Nateglinide. The estimation of Nateglinide was carried outby same solvent like phosphate buffer ph is 6.8(method I) at 239nm, (method II) at 248nm and (method III) at 217nm. And these methods were found to be linear in the range of 2-16μg/ml, for method I,2-12 for method-II and 2-16μg/ml for method III. And Beers law rangewere found to be 1-15μg/ml, 1-15μg/ml, and10-250μg/ml, and with mean recovery of 99.84 %,99.45 % and 100.3 % of Nateglinide for methods I, II and III respectively. The developed method was validated according to ICH guidelines and it found to be accurate and precise Thus the proposed method can be successfully applied for simultaneous determination of Nateglinide and in routine analysis work.