ISSN: 2249–9504
CAS CODEN: IJPCDX

SPECTROPHOTOMETRIC DETERMINATION OF TERBINAFINE HCL, TELMISARTAN ANDRAMIPRIL THROUGH REDOX REACTIONS USING BROMATE-BROMIDEMIXTURE

Abstract

Author(s): Afaf Abou-elkheir*, Hanaa M Saleh, Magda M El-henawee, Basma El-Sayed Ghareeb

ABSTRACT Two visible spectrophotometric methods (A,B) were developed for the analysis of some drugs, namely Terbinafine HCl, Telmisartan and Ramipril based on their reactivity with bromine, generated in situ by the action of the acid on bromate–bromide mixturefollowed by the determination of unreacted bromine by reacting with a fixed amount of either methylene blue (MB) and measuring the absorbance at 678 nm for Terbinafine HCl and Ramipril and at 668 nm for Telmisartan(method A) or methyl red (MR) and measuring the absorbance at 517 nm (method B). Beer’s law is valid within the concentration ranges of 1-3, 2-18 and 28-68μg/ml for Terbinafine HCl, Telmisartan and Ramipril, respectively (method A) and the concentration ranges of 0.5-2.5 and0.3- 3.6 μg/ml for Terbinafine HCl and Telmisartan, respectively(method B). Correlationcoefficients, limits of detection and quantification are also reported. Recovery results were statistically compared with those of areference method by applying Student’s t- and F-test.

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