Author(s): Nehad R. Elyazji and Ismail Abdel-Aziz
Gentamicin is an aminoglycosideantibiotic, used to treat many types of bacterialinfections, particularly those caused by Gram-negativeorganisms. Gentamicin is also ototoxicand nephrotoxic, with this toxicity remaining a major problem in clinical use .The present study is aimed to assess the risk factors, diagnosed hematological and biochemical alterations associated with Gentamicinand/or Novalgin injection in rabbits. Male rabbits were assigned to one of five groups (12 rabbits each) which received subcutaneous injections for 10 and 20 days: Control; (G) Gentamicin alone; (N) Novalgin alone; (G + N) Gentamicin + Novalgin; (G rec) Gentamicin recovery; (N rec) Novalgin recovery and (G + N rec) Gentamicin + Novalgin recovery. In (G rec) and (G + N rec), rabbits recovered for 14 days after the last injection. Upon Gentamicinand/or Novalgin injection, there were a general decrease in RBCs count, Hb content, hematocrit (HCT) value, mean corpuscular hemoglobin (MCH) and WBCs total count. Whereas mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and blood platelets were increased. It is clearly pronounced that Gentamicinand Novalgin injection is more effective in experimental duration of 10 & 20 days. Administration of Gentamicinand/or Novalgin caused significant increase of urea, uric acid, creatinine concentration and ALP activity as compared to control. Whereas, there were a non significant decrease intotal protein in animals injected withGentamicinor Novalgin and decreased significantly in animals injected withGentamicinand Novalgin. Signs of improvements in hematological parameters urea, uric acid, creatinine and total protein and alkaline phosphatase were noticed after drugs stopped.