ISSN: 2249–9504
CAS CODEN: IJPCDX

SOLVENT EVAPORATION METHODFOR AMORPHOUS SOLID DISPERSIONS:PREDICTIVE TOOLSFOR IMPROVE THE DISSOLUTION RATE OF PIOGLITAZONE HYDROCHLORIDE

Abstract

Author(s): Singh Chhater* and Kumar Praveen

The present study was aimed to improve the solubility of Poorly water soluble drug (pioglitazone HCl), by the solvent evaporation method in order to achieve increased dissolution rate, improved solubility, bioavailability and stability. The main purpose of this investigation was to increase the solubility and dissolution rate of Pioglitazone HCl by the preparation of its solid dispersion with polyvinyl pyrrolidone K30 using solvent evaporation methods. FT-IR spectra revealed no chemical incompatibility between drug and polyvinyl pyrrolidone K30. Drug-polymer interactions were investigated using differential scanning calorimetry (DSC), Powder X-Ray Diffraction (PXRD).

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