ISSN: 2249–9504
CAS CODEN: IJPCDX

SERUM LACTATE DEHYDROGENASE AND ADENOSINE DEAMINASE AS PREDICTORS OF HEMOLYSIS IN CHILDREN WITH HEMOLYTICANEMIA

Abstract

Author(s): Gargi Sen1, Indranil Chakraborty2, Santa Saha-Roy3, Subhendu Choudhury4, Debashis Bhattacharya5and Kaushik Bannerjee

Tissue-specific increase in normal adenosine deaminase (ADA) is associatedwith hereditary hemolytic anemia. Lactate dehydrogenase (LDH) is clinical marker of intravascular hemolysis. Both are associated with pulmonary hypertension in hemolytic anemia. To validate the relevance of ADA and LDH as early predictors of hemolysis by ascertaining their dose response with severity of anemia. ADA was estimated by Colorimetric Method of GIUSTI and GULANI based on Bertholet Reaction while LDH was estimated enzymatically. Complete hemogram was done in Beckman coulter. ADA and LDH were significantly higher in all types of anemia but only ADA was significantly raised in hemolytic anemia (p < 0.001). Both correlated significantly with hemoglobin percentage but only ADA correlated significantly with reticulocyte count. ADA was better index of the severity of hemolytic anemia.

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