ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

RP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF ETIZOLAM AND PROPRANOLOL IN PURE AND ITS TABLET DOSAGE FORM

Abstract

Author(s): D. Umamaheshwari*, B. Jayakar

A new reverse phase high performance liquid chromatography method has been developed for the simultaneous estimation of Etizolam and propranolol from their tablet formulation . The developed method was carried out on a C18(250x4.6mm) 5.0 µm column using a mobile phase of 0.02M sodium phosphate w/v : acetonitrile. (60:40) pH 6.5 with triethylamine. The flow rate was 1.0 ml/min with detection at 240 nm. The retention time for Etizolam 3.183 mins and for propranolol hydrochloride 4.863 mins.Etizolam and propranolol showed a linear response in the concentration range 4-50µg/mL, 4.5-50µg/mL respectively. The result of analysis have been validated statiscally and by recovery studies. The mean recoveries foµnd for Etizolam was 99.98% and for propranolol was 100.09%. The developed method was found to be simple, accurate, precise and selective for simultaneous estimation of Etizolam and propranolol Hcl in tablets.

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