ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFIXIME TRIHYDRATE AND LINEZOLID IN TABLET DOSAGE FORM

Abstract

Author(s): SatishA. Pateland Jinalben V Patel*

A simple and sensitive reversed phase High Performance Liquid Chromatographic method has been developed and validated for the simultaneous analysisof the Cefiximetrihydrate (CEF) and Linezolid (LIN) in tablet dosage form. The separation was carried out using mobile phase consisting of buffer and methanol with pH 2.5 in the ratio of 70:30, v/v. The column used was ACE 5 C18, (150 mm x 4.6 mm i.d., 5 μm) with flow rate 1.2 ml/min using PDA detection at 250 nm. The method was linear over a concentration range of 23.33 40 μg/ml and 70 120 μg/ml for CEF and LIN, respectively. The retention time of CEFand LIN were found to be 3.30 min and 8.07 min, respectively. Results of analysis were validated statistically and by recovery studies. The mean recovery was 101.9 ± 0.82 and 102.6 ± 1.15 for CEF and LIN, respectively. The limit of detection (LOD) and the limit of quantification (LOQ) for CEF and LIN werefound to be 0.78 and 2.37 μg/ml and 2.42 and 7.34 μg/ml, respectively. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate which is useful for the routine determination of CEF and LIN in its pharmaceutical dosage form.

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