Author(s): Amal Abdel-Aziz El-Mahdy
High fat diet is a public health problem worldwide and considered as a risk factor for many diseases. This study aimed to investigate the effectiveness of L.arginine in high fat-fed rats. The present study indicate that after high fat diet (25%), there are significant increase in concentration of glucose, triglycerides, total cholesterol, corticosterone and urea as well as the body weights increased. Furthermore liver and adipose tissue differently changed than normal.Supplementation of L.arginine (1.2%) in drinking water markedly reduces glucose, triglycerides, total cholesterol, and Urea levels to more or less than normal. This modulation of metabolic syndrome due to the presence of nitric oxide (NO) is synthesized from L.arginine which simulate glucose uptake as well as glucose and fatty acid oxidation in skeletal muscle, heart, liver and adipose tissue, inhibit the synthesis of glucose, and fat in target tissues (e.g., liver and adipose); and enhance lipolysis in adipocytes. Thus, an inhibition of (NO) synthesis causes hyperlipidemia and fat accretion in rats, whereas dietary arginine supplementation reduces fat mass in high fat-fed rats and improvement metabolic syndrome.