Author(s): Harpreet Kaur and Monika Gupta*
Cancer is the leading cause of death in both developed and developing countries. Researchers are still developing new and more effective drugs to combat this disease. Thiosemicarbazones and their analogs have shown various potential medical applications but presently the areas in which thiosemicarbazones receiving more attention is its use against cancer. Thiosemicarbazone inhibit Topoisomerase IIa and Ribonucleotide reductase enzymes. Structural variations of these compounds were found to be highly selective in their action. The present review gives a brief outline of the recent advances in various thiosemicarbazones as anticancer agents.