ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

PREPARATION AND EVALUATION OF OPHTHALMIC INSERTS OF BRIMONIDINE TARTRATE

Abstract

Author(s): P. Rameshbabu, Sayani Bhattacharyya*, KR. Nagapriya

The purpose of this work was to develop an ocular insert for the treatment of glaucoma with αagonist Brimonidine tartrate. Nine such ocular inserts were prepared by solvent casting method using polymers Hydroxyethyl methacrylate (HEMA), EUDRAGITRL-100,EUDRAGIT RS-100, plasticizers, Dibutyl phthalate(DBP), PEG 400 and Propylene glycol and water as solvent. These formulations were evaluated for mechanical properties like tensile strength, % elongation at break, strain, folding endurance, physicochemical properties like thickness, weight variation, surface pH, %moisture absorption, compatibility, and drug content. In vitro drug release was carried out and the release kinetics was studied which revealed case II transport. All the formulations were taken for sterilization and subjected to eye irritancy test on Rabbits. Inserts containing HEMA plasticized with DBP showed better shape retaining properties and more controlled release of drug. On the basis of evaluation it was found that tensile strength and folding endurance of the inserts prepared with plasticizer DBP was high compared to inserts prepared with other plasticizer and inserts containing HEMA showed good shape retaining properties than other polymers used in the study

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