ISSN: 2249–9504
CAS CODEN: IJPCDX

PREPARATION AND EVALUATION OF MATRIX TABLET OF A THIRD GENERATION CEPHALOSPORIN DRUG

Abstract

Author(s): Jaya Parasgar* , Kanhan Mathuriya, Jagriti Yadav, Rahul Mathur, Mithun Bhowmick and Jagdish Chandra Rathi

Cefixime Trihydrate (CFT) is an orally active third generation cephalosporin. It has plasma half-life of 3-4 hrs. It is active against Gram+ve as well as Gram-ve bacteria. CFT is a third generation oral cephalosporin antibiotic that inhibits wide variety of gram-positive and gram-negative bacteria, especially most members of the family Enterobacteriaceae, including strains producing the common plasmid-mediated β-lactamases. It is well tolerated and one of the best 3rd generation cephalosporin to be available in oral form. CFT has widely been used in the treatment of respiratory and urinary tract infections. The objective of the present work is to design sustained release matrix tablets of CFT by incorporating drug in a matrix made up of release retardant polymers, which prolong drug release leading to minimization of the peak and valley effect in the plasma and provide patient convenience. The effect of combination of polymers on parameters like release pattern, release mechanism of the drug were studied. Since no report or literature is available regarding matrix based once a day formulation of CFT using polymers Eugragit RS 100, Eugragit RL 100 HPMC and PVP K30 to improve patient compliance with better efficacy and negligible side effects

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