ISSN: 2249-9504
CAS CODEN: IJPCDX

PREPARATION AND CHARACTERIZATION OF SUSTAINED RELEASE PLGA-LOADED MICROPARTICLES CONTAINING LEUPROLIDE ACETATE

Abstract

Author(s): Srujan Peddi1, K. Narendra Kumar Reddy1*, Sumit Shah2, K. Sravani Shilpa2and K.Madhuri2

The objective of the present work was to formulate and evaluate sustained release leuprolide acetate microspheres for treating prostate and breast cancer effectively. In order to improve patient compliance with fewer side effects like pain and hot flashes from the marketed product of implants. Sustained release Leuprolide acetate microspheres for two months depot which had been designed based on disease condition were prepared in the form of microspheres for subcutaneous administration for sustained release. Different formulations were prepared by following Solvent Evaporation technique (double emulsion) using synthetic biodegradable polymer like Poly(Lactide-co-Glycolide) acid. The formulations were evaluated for percentage yield, entrapment efficiency, surface morphology (SEM), particle size analysis, In-vitro drug release and stability studies. The in-vitro release of drug from the formulations were studied in pH7.4 saline phosphate buffer solution, and it was found that the prepared microspheres were able to sustained the release of the drug upto two months of about 95.6%. The release of the drug from the microspheres was found to follow zero order kinetics. The optimized formulation of the microspheres containing polymer and drug was found to be compatible from FTIR studies.

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