ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

PLASMA GLYCOPROTEIN INHIBITORS AS A NEW TARGET FOR OPTIMAL DRUG DELIVERY

Abstract

Author(s): Alla Narayana Rao*, Y. Bhargav, B. Sai Krishna, M. Prasanna Teja, MSC. Bose

Plasma glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP Binding Cassette (ABC) super family that functions specifically as carrier mediated primary active efflux transporter. It is widely distributed throughout the body and has a diverse range of substrates. Several vital therapeutic agents are substrates to P-gp and their bioavailability is lowered or a resistance is induced because of protein efflux. Hence P-gp inhibitors were explored for overcoming multidrug resistance and poor bioavailability problems of the therapeutic P-gp substrates. This review represents a brief discussion on P-gp mediated drug transport and how it hinders the success of various therapies. Its main focus is on various strategies used to improve the drug delivery and targeting.

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