ISSN: 2249–9504
CAS CODEN: IJPCDX

PHYTOCHEMICAL EVALUATION AND INVITROANTIBACTERIAL SCREENING OF WRIGHTIA TINCTORIA (ROXB.) R. BR. AGAINST ENTERIC PATHOGENS

Abstract

Author(s): A. John De Britto*andSteena Roshan Sebastian

Theenteric pathogens are responsible for major health problems in most of the countries. Pathogens develop resistance against the antibiotics, and its continuous use may cause severe side effects. This urged to find alternate means to control the infection.The leaves of Wrightia tinctoria (Roxb.) R. Br. taken from an herbal gardenwas evaluated against five enteric pathogens. Antibacterial activities of the extracts were determined by the agar disc diffusion method. Chlortetracycline (5 mcg/disc) was used as positive control for comparison of the inhibition zones. Phytochemical screening of the plant leaves revealed the presence of steroids, reducing sugar, alkaloids, phenolic compounds, flavonoids, saponins and tannins. Theextract showed efficient antibacterial activity against Staphylococcus aureuswith maximum zone of inhibition. 10μg/ml of the methanol extract was observed to be the minimum inhibitory concentration against Staphylococcus aureus, Shigella dysenteriaeand Shigella boydii

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