ISSN: 2249–9504
CAS CODEN: IJPCDX

PERMEABILITY ASSESSMENT OF GRISEOFULVIN MICROEMULSION THROUGH RAT SKIN

Abstract

Author(s): Eskandar Moghimipour*, AnayatollahSalimi and Somayeh Hassanvand

Griseofulvin is an antifungal agent that inhibits fungal mitosis. It has been recommended orally for the treatment of fungal disease. It is a highly lipophilic, poorly soluble drug with low oral bioavailability. Therefore the aim of the present investigation was to increase its solubility by using microemulsion system for topical drug delivery. Microemulsion (ME) formulations were prepared by mixing of appropriate amounts of surfactants including span 20, labrasol, co-surfactant such as pleurololeic and oil phase including oleic acid and transcutul P (10:1). The prepared MEs were evaluated regarding their particle size, viscosity and permeation of the drug through skin of male Swiss Albino rats. The mean droplets sizes of MEs formulations were in the range of 37.2 to 94.31 nm and the mean of viscosities of MEs formulations were in the range of 264.3 to 385.2 cps.Comparison between Jssof simple solution control group and MEs indicated that formulation of the drug in form of me may significantly improve drug permeation through rat skin.It was concluded that formulation factors including water and oil percentages, and also surfactant to co-surfactant ratio had an impact on drug permeability through biologic membranes.

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