Author(s): Sayyed Hussain1, Shivaji Jadhav1*, Megha Rai2 and Mazahar Farooqui2, 3
Herein we wish to report an efficient, eco-friendly and cleaner method for rapid knovenagel condensation of substituted 2-chloroquinoline-3-carbaldehyde with ethyl cynoacetate under ultrasonic irradiation in solvent-free medium by using N-ethyl diisopropyl amine (NEDA) as catalyst within short time period (14-20 min.) at room temperature. The overall progress of reaction was monitored by TLC and formation of compound III(a-h) was confirmed by physical constants and spectroscopic studies. Compared with traditional method, this method is more convenient and reaction can be carried out in higher yield, shorter reaction time and milder condition, without generation of pollution and safer to analyst. From these features present methods can be correlated for safer and efficient synthesis of other products.