ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

ONE-POT MULTI-COMPONENT SYNTHESIS OF [1,4]BENZOXAZINEISOXAZOLE HYBRIDS AND THEIR ANTIBACTERIAL ACTIVITY

Abstract

Author(s): Gopi Iloni , Sreenivas Vasam, Veeranna Guguloth and Ravinder Vadde*

A one-flask strategy for the synthesis of novel 4-((3-(aryl) isoxazol-5-yl) methyl)-2H-benzo[b][1,4] oxazin-3(4H)-one derivatives (4a-j) were synthesized by the Cu(I)-catalyzed reaction of in situ generated nitrile oxides with in situ generated N-propargyl 1,4-benzoxazine in good yields and their antibacterial activity was investigated. Among all the synthesized compound 4j have shown very good inhibition against all the tested Gram-positive and Gram-negative bacterial strains with MIC values ranging from 3.12 to 12.5 µg mL-1 . Compound 4f against B. subtilis and K. pneumoniae with MIC value 6.25 µg mL-1 and Compound 4g have shown potent activity against B. subtilis and E. coli with MIC value 12.5 µg mL-1 . Remaining compounds are shown moderate to poor activity as compared to the standard drug Streptomycin.

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