ISSN: 2249–9504
CAS CODEN: IJPCDX

ONCE-DAILY SUSTAINED RELEASE MATRIX TABLETS OF GLIMEPIRIDE - FORMULATION AND IN VITRO EVALUATION

Abstract

Author(s): S. Bhagat*, D. Nayak and R. Keny

The present investigation aims to formulate Sustained Release matrix tablets of Glimepiride in a matrix design utilizing different percentages of hydrophilic polymers. Based on the preformulation studies, 10 optimized formulations were prepared by direct compression using different controlled release polymers such as HPMC K4M, HPMC K100 LV and Sodium Alginate alone and in combination. Comparative evaluation of the drug release from the various formulations was conducted and the performance evaluated. The data obtained from dissolution studies was fitted in 5 models i.e. Zero Order, First Order, Higuchi Matrix, Korsmeyer Peppas and Erosion plot. Mathematical analysis of release kinetics indicated that nature of drug release from matrix tablets was dependent on drug diffusion and polymer relaxation, hence followed non-fickian or anomalous release approaching Zero Order Kinetics. The cumulative percentage drug release data revealed that formulations F5, F8 and F9 were highly effective in retarding drug release up to 24 hours with 97.47 %. 99.38 % and 98.76 % respectively. Stability studies performed at 40 degrees/75 % RH for a month exhibited absolutely no significant variations

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