ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

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METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF B-GROUP VITAMINS AND ATORVASTATIN INPHARMACEUTICAL SOLID DOSAGE FORM BY RP-HPLC

Abstract

Author(s): Kamble Reema*, Vaidya Itishree, Nangude Shantaram and Gaikwad Jagdish

A simple and sensitive RP-HPLC method was developed and Validated for the simultaneous determinationof B-group vitamins like Pyridoxine hydrochloride (B6), folic acid(B9), Methylcobalamine (B12) and Atorvastatin(ATO) in Atherochek Tablets. The Methylcobalamine (B12) was determined separately because of its low concentration in tablets. RP-HPLC analysiswas performed with a Waters, Alliance e2690 HPLC system, equipped with a UV/VIS Waters 2489 detector. The procedures for the determination of B6, folic acid & Atorvastatin were carried out on a Inertsil ODS-3, C-18 (250x4.6mm, 5miron) column and the Detection wavelength at 254 nm for Atorvastatin,vit B6,folic acid and 265 nm for Vit. B12. The obtained results and statistical parameters for all the investigated vitamins of the B-group and Atorvastatin in Atherochek tablets were satisfactory. The methods were validated according to ICH guidelines.

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