ISSN: 2249–9504
CAS CODEN: IJPCDX

LIPOPROTEIN (a) LEVELS IN ACUTE MYOCARDIAL INFARCTION PATIENTS ADMITTED IN INTENSIVE CARDIAC CARE UNIT OF TRIPURA MEDICAL COLLEGE: A CLINICAL STUDY TO EVALUATE LIPOPROTEIN (a) AS RISK FACTOR FOR AMI AND COMPARISION WITH HEALTHY SUBJECTS

Abstract

Author(s): Tapan Debnath1, Sankar Roy2, Biswajit Majumdar2* , Avik Chakraborty2, Partha Sarathi PaL3 and Mohan Chandra Mondal3

Lipoprotein (a) , a prominent marker of cardiovascular accident, was first described by Berg in 1963(3). Lipoprotein(a) [Lp(a)] has been considered as one of the distinguished signature in myocardial infarction and for many years.1. Owing to incomplete scientific evidence in clinical practice, screening for and treatment of high Lp(a) levels is primarily essential. Aims and Objectives: Aim of our study is 1.To determine the level of Lp (a) in patients with acute myocardial infarction and compare it with matched healthy control group .2.To find out the significance of Lipoprotein (a) level among the patients of Acute Myocardial infarction (AMI) of Agartala, Tripura, North East region of India.3.To compare the Lipoprotein (a) level amongst the AMI patients with ethnic variability of non-tribal and tribal AMI patients of Agartala, .4.To find out the significance of Lipoprotein (a) level in routine investigations of AMI patients. Materials and Methods: Fourty two (42) patients with acute myocardial infarction were selected from a series of consecutive patients admitting in the coronary care unit (CCU) of Tripura Medical College and DR. BRAM Teaching Hospital. Lp(a) was quantified by immunoturbidiometric method. Results:Serum LP(a) concentration in control group is 30.50+_ 25 mg/dl with maximum 134mg/dl . In the case group AMI patient group in both male& female patients with average mean LP(a) concentration is 78.95+_45 mg/dl, the maximum value is 485 mg/ dl. Discussion: There is significant difference between the two group. ( p< 0.05). LP-(a) concentration level in patients with AMI is higher than the control group. An elevated Lp(a) concentration is associated AMI and a risk factor for AMI ., suggesting that Lp(a) may play an important role in the genesis of thrombotic coronary occlusion and the occurance of AMI. Conclusion: So it is suggested to make LP(a) serum level determination test as a routine laboratory test for identification of risk factor for AMI and to follow proper treatment to reduce LP(a) level in serum.

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