ISSN: 2249–9504
CAS CODEN: IJPCDX

INVESTIGATION OF ANTIOXIDANT OF NOVEL 4-[2-(2-THIENYLCARBONYLOXY)-3-METHOXYBENZYLIDENEAMINO]-4,5-DIHYDRO1H-1,2,4-TRIAZOL-5-ONE DERIVATIVES

Abstract

Author(s): Abdurrahman Gurbuz , Muzaffer Alkan, Sevda Manap, Gul Ozdemir. Ozlem Gursoy-Koland Haydar Yuksek

A series of novel 3-alkyl(aryl)-4-[2-(2-thienylcarbonyloxy)-3-methoxybenzylideneamino]-4,5- dihydro-1H-1,2,4-triazol-5-ones (4) were synthesized from the reactions of 3-alkyl(aryl)-4- amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) with 2-(2-thienylcarbonyloxy)-3-methoxybenzaldehyde (3). Then, the acetylation reactions of compounds 3 were investigated and 1- acetyl-3-alkyl(aryl)-4-[2-(2-thienylcarbonyloxy)-3-methoxybenzylideneamino]-4,5-dihydro-1H1,2,4-triazol-5-ones (5) were obtained. The structures of thirteen new compounds were characterized from IR, 1H NMR, 13C NMR and UV spectral data. In addition, the synthesized new 4 and 5 type compounds were analyzed for their in vitro potential antioxidant activities in three different methods; including 1,1-diphhenlyl-2-picryl-hydrazyl free radical (DPPH.) scavenging, reducing activity by Fe+3 – Fe+2 transformation and ferrous metal (Fe+2) chelating activities

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