ISSN: 2249–9504
CAS CODEN: IJPCDX

IMPROVED ANTIBACTERIAL EFFICACY OF A NOVEL FORMULATION - SYNERGISTIC EFFECT OF HERBS

Abstract

Author(s): Manjulika Yadav, Sanjukta Chatterji, Deepak Kumar Yadav, Anamika Mubayi and Geeta Watal*

Herbal formulations have attained widespread acceptability as therapeutic agents being a part of traditional system of medicine. Synergistic effect of individual counterparts of formulations leads to the development of combination therapy. In the present study, we investigated the synergistic effect of two medicinal plants viz. Murraya koenigii and Sesamum indicum for their in-vitro antibacterial activity. In-vitro antibacterial activity was assessed for a range of varied concentrations of formulation against different bacterial strains and the results were compared with standard drug, ampicillin as well as with individual plants. The formulation was found to have significant efficacy in comparison to the individual plants. The minimum inhibitory concentration of formulation was 0.075mg/ml against Klebsiella pneumoniae and Escherichia coli which is very low as compared to individual plants. This formulation with enhanced potential to reduce bacterial infections could be developed as a novel therapeutic agent.

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