ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF CROTON SPARCIFLORUS ON DEN INDUCED HEPATOTOXICITY IN WISTAR ALBINO RATS

Abstract

Author(s): Abi Beaulah G1, Mohamed Sadiq A2, Madhan Chakkaravarthy V3 and Jaya Santhi R1*

The methanolic extract of Croton sparciflorus was studied for the hepatoprotective activity using DEN induced liver damage in wistar albino rats. Methanolic extract of this plant showed significant (p<0.05) hepatoprotective effect by lowering the serum levels of various biochemical parameters like AST, ALT and ALP in the selected model. These biochemical observations were confirmed by histopathological examinations of liver sections and are comparable with the standard hepatoprotective drug Silymarin which served as a positive control. The results suggests that the biologically active phytoconstituents such as flavonoids, glycosides, alkaloids present in the methanolic extract of plant which is confirmed from the qualitative analysis may be responsible for the significant hepatoprotective activity. The results justify the use of the plant as a hepatoprotective agent in folklore practice against liver disorder.

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