ISSN: 2249–9504
CAS CODEN: IJPCDX

GASTROPROTECTIVE ACTIVITY OF MICHELIA NILAGIRICA IN RATS: POSSIBLE INVOLVEMENT OF H+-K+-ATPASE INHIBITION

Abstract

Author(s): SK. Aminabee, A. Lakshmana Rao, M. Chinna Eswaraiah

Objective: Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is
investigated for protective effect and mechanism as gastroprotective agent. Methods: Adult male
Wistar rats weighing 120-180 gm were used for the experiment. All the animals were fasted for 24
hrs prior to the experiments. Groups were treated with different fractions 30 min before Aspirin at a
dose of 500 mg/kg was administered. After 3 hrs, of Aspirin treatment, rats were anesthetized
under mild ether and 748sacrificed via cervical decapitation the animals were sacrificed by cervical
dislocation and the stomach was incised along the greater curvature and measure ulcer index.
Gastroprotective activity is also found out by pylorus ligation induced ulceration. Results: The
present study revealed that fraction B (150 mg/kg) shown maximum percentage of protection
against aspirin induced ulcer and pylorus ligation induced ulceration. Conclusion: Protection may
be due to presence of valuable terpinoids that was found out in phytochemical study.

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