Abstract
Author(s): S. Janardhanan, K.Elango, Vadivel and B.Suresh
A peptic ulcer is an excoriated area of the mucosa caused by the digestive action of gastric juice in the stomach. The peptic ulcer is gastrointestinal tract multi factorial disease, which caused by tobacco smoking, alcohol intake, spicy foods, and NSIAD’S.T The several herbal formulations derived from Ayurveda and its additional systems of medicine, not yet to be scientifically validated that they have exhibited anti-ulcer activity.The present study was undertaken to investigate anti-ulcer activity of hydro alcoholic extract of Heliotropiumindicumon four different anti-ulcer models. The anti-secretary, acetic acid induced ulcer and cysteamine induced duodenal ulcer results have been expressed that the crude hydro alcoholic extract of Heliotropiumindicumdose levels200 and 400mg/kg were dose dependent manner significantly decreased in the ulcer index and ulcer scoring (**P<0.05 and***P<0.001) when compared to control and positive control. The physicochemical studies results have suggested that the crude hydro alcoholic extract of Heliotropiumindicumdose levels 200 and 400 mg/kg, on offensive (Gastric PH & k+ concentration) and defensive (Gastric volume, Free acidity, Total acidity, Na+concentration) factors were indicated (*P<0.01,**P<0.05 and***P<0.001), antiulcer activity when compared to control and positive control. The biochemical parameters results have been expressed that the crude hydro alcoholic extract of Heliotropiumindicumdose levels 200 and 400 mg/kg, offensive (Pepsin, Carbohydrate: Proteins, Total Carbohydrates, Total Hexoses, Hexosamine, Fucose, Non Sufhydryl group and Sialic acid) and defensive ( Catalase, Superoxide Dismutase, Lipid Peroxidase, Mucus barrier) factors were indicated (*P<0.01,**P<0.05 and***P<0.001) antiulcer activity when compared to control and positive control. In another hypothesis, the pharmacological mechanism could be attributed either direct or indirect anti-ulcer activity.