ISSN: 2249-9504
CAS CODEN: IJPCDX

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Citations : 3566

International Journal of Pharmaceutical, Chemical and Biological Sciences received 3566 citations as per google scholar report

International Journal of Pharmaceutical, Chemical and Biological Sciences peer review process verified at publons

FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING ACECLOFENACTABLETS PREPARED BY SOLID DISPERSION BY USING MANNITOL

Abstract

Author(s): M.Ratnaparkhi*and R. Dhomse

Aceclofenac is new nonsteroidalanti-inflammatory drug acting by an inhibition of the synthetic of prostaglandins by inhibiting the activity of the enzyme, cyclooxygenase-2(COX-2). It is more selective for COX 2 than COX-1. Aceclofenac is practically insoluble in water and peak blood level rechease between 1.25 to 3 hrs after oral administration. It is practically insoluble in aqueous fluids. In the case of poorly water-soluble drugs, dissolution is the rate-limiting step in the process of drug absorption.The solid dispersion approach has been widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly water-soluble drugs. To improve the dissolution of aceclofenac through the formulation of solid dispersion using water soluble carriers like mannitol by melt solvent methods and to convert the optimized solid dispersion in fast dissolving tablet formulation. The formulated tablets showed rapid in vitro drug dissolution and dissolution efficiency within 30 min.

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