ISSN: 2249–9504
CAS CODEN: IJPCDX

FORMULATION AND OPTIMIZATION OF CLOPIDOGREL BISULFATE IMMEDIATE RELEASE TABLET

Abstract

Author(s): Sravani Shilpa. K1*, Anand Kumar. M2 and Garigeyi. P2

This investigation is undertaken with an aim to develop pharmaceutically equivalent, stable, cost effective and quality improved formulation of clopidogrel bisulfate immediate release tablets The current study involves preparation and evaluation of clopidogrel bisulfate tablets, comparison of dissolution rate of optimized formula with innovator’s product and estimation of similarity and difference factors.The similarity and dissimilarity factor obtained for clopidogrel bisulfate was found to be within the standards.The formulation F-6 exhibited similar release profile to that of innovators product at each time point. Hence, F-6 was considered as the best formulation.

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