Author(s): M. Parvathi
The purpose of this research was to prepare a floating drug delivery system of Metformin hydrochloride in order to increase the gastric residence time (GRT) and comparison of naturaland synthetic polymer for better sustained effect. The tablets were prepared by wet granuation compression. The hardness of all formulations was found to be in the range of 3.4±0.2 –5.5±0.1 kg/cm2. All formulations (F1 to F12)prepared by wet granulation method, batchF2was best formulation and showed very slow release i.e. 96.52% in 12 h.The release behavior of the natural and synthetic polymers were compared according to obtained data. The release data were subjected to different models zero order, first order Higuchi and Pappas in order to evaluate their release kinetics and mechanisms. The drug release was observed by fickian diffusion mechanism. A combination of HMC K 100 and gellan gum shows better sustained release when compared with remaining polymers.The developed floating tablets of Metformin Hydrochoride may be used in clinic for prolonged drug release for at least 12hrs, thereby improving the bioavailability and patient compliance.