ISSN: 2249–9504
CAS CODEN: IJPCDX

FORMULATION AND EVALUATION OFPROPRANOLOL HYDROCHLORIDEMICROSPHERESBY IONIC GELATION TECHNIQUE

Abstract

Author(s): Ramalingam Nethaji*, Shahir Shareef, Manikandan Palanivelu,Subramaniam Surendiran N and Babu Ganesan

Frequent administration and variable low bioavailability after oral administration of conventional dosage forms can be overcome by microspheres formulation. Propranolol Hydrochloride is nonselective beta blocking anti-hypertensive drugand used for angina pectoris, myocardial infraction, migraine prophylaxis, glaucoma. The aim of the present work is formulate and evaluate microspheres of Propranolol Hydrochloride to achieve sustained release. Propranolol hydrochloride microspheres loaded using combination of sodium alginate, Sodium carboxy methyl cellulose, Hydroxyl propyl methyl cellulose by ionic-gelation technique using calcium chloride as a cross linking agent. Eight formulations (F1-F8) were prepared using different polymers ratio. Depend on drug polymers ratio, the percentage yield were found to be in range between 90.17±0.16% to 98.83±0.26% and entrapment efficiency were 60.89±0.86%to 88.49±0.28% respectively.SEM study shows microspheres are spherical in nature and size distribution between 31.05±0.5 to 73.23±0.67µm. In-vitro drug releasestudies carried out at different pH for a period of 12 hours. All formulationsshownsustained release characteristics and particularly F8 formulated microspheres found high rate and extent of drug releaseand good fit to Higuchi model follows first order kinetics whichexhibitFickian diffusion mechanism. There is nophysical changeswere observed during stability studies and swelling indices has been done and varied between the formulations.

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